منابع مشابه
Clamp loaders and sliding clamps.
A coherent view of the structure and function of DNA polymerase processivity factors (sliding clamps and clamp loaders) is emerging from recent structural studies. Crystal structures of sliding clamps from the T4 and RB69 bacteriophages, and from an archaebacterium expand the gallery of ring-shaped processivity factors and clarify how the clamp interacts with the DNA polymerase. Crystallographi...
متن کاملThe PCNA-RFC families of DNA clamps and clamp loaders.
The proliferating cell nuclear antigen PCNA functions at multiple levels in directing DNA metabolic pathways. Unbound to DNA, PCNA promotes localization of replication factors with a consensus PCNA-binding domain to replication factories. When bound to DNA, PCNA organizes various proteins involved in DNA replication, DNA repair, DNA modification, and chromatin modeling. Its modification by ubiq...
متن کاملNegligent Class Loaders for Software Evolution
Modern software should be dynamically evolvable. The onward sweep of technology, introducing new features, and fixing immortal security holes, drive this evolution. Moreover, practical demands of on-the-fly changes of running applications eagerly encourage the evolution since the downtime of commercial software directly causes big losses. Enabling the evolution of software components is a major...
متن کاملOverproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae.
The replication clamp PCNA and its loader RFC (Replication Factor C) are central factors required for processive replication and coordinated DNA repair. Recently, several additional related clamp loaders have been identified. These alternative clamp loaders contain the small Rfc2-5 subunits of RFC, but replace the large Rfc1 subunit by a pathway-specific alternative large subunit, Rad24 for the...
متن کاملTectonic evolution of the Khoy ophiolitic complex, NW Iran
The Khoy Ophiolitic Complex (KOC) as a part of Tethyan, Izmir-Ankara- Erzincan and Bitlis-Zagros sutures of South East (SE) Turkey is broadly exposed around Khoy region (NW Iran). This complex comprises dismembered fragments of mantle lithosphere, obducted oceanic lithosphere and parts of volcanic arc remnants. The Khoy Ophiolitic Complex can be structurally divided into two major eastern and w...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a513-b